Article: HLA Class II Antigens and Their Interactive Effect on Perinatal Mother-To-Child HIV-1 Transmission.
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Luo M; Embree J; Ramdahin S; Bielawny T; Laycock T; Tuff J; Haber D; Plummer M; Plummer FA
PLoS ONE, 2015
10.1371/journal.pone.0126068.t007
Interactive effect of DRB discordance, DRB1*1503 phenotype and specific class II alleles on perinatal mother-child HIV transmission.
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|
Children with DRB1*1503- mother (n = 191) |
Children with DRB1*1503+ mother (n = 62) |
| |
HIV+ (n = 66) |
HIV- (n = 125) |
p value |
odds ratio (95%CI) |
HIV+ (n = 26) |
HIV- (n = 36) |
p value |
odds ratio (95%CI) |
| DRB_ discord |
45 (68.2%) |
115 (92.0%) |
0.00002 |
0.186 (0.081-0.427) |
18 (69.2%) |
25 (69.4%) |
0.986 |
0.99 (0.332-2.956) |
| |
DRB1*1503- children (n = 195) |
DRB1*1503+ children (n = 56) |
| |
HIV+ (n = 66) |
HIV- (n = 129) |
p value |
odds ratio (95%CI) |
HIV+ (n = 24) |
HIV- (n = 32) |
p value |
odds ratio (95%CI) |
| DRB_ discord |
49 (74.2%) |
119 (92.2%) |
0.0006 |
0.242 (0.104-0.566) |
14 (58.3%) |
21 (65.6%) |
0.577 |
0.733 (0.246-2.184) |
| |
DRB1*1503- mother and children (n = 174) |
DRB1*1503+ mother and children (n = 80) |
| |
HIV+ (n = 59) |
HIV- (n = 115) |
p value |
odds ratio (95%CI) |
HIV+ (n = 33) |
HIV- (n = 47) |
p value |
odds ratio (95%CI) |
| DRB_discord |
40 (67.8%) |
105 (91.3%) |
0.00008 |
0.201 (0.086-0.468) |
10 (30.3%) |
11 (23.4%) |
0.490 |
0.703 (0.258-1.917) |
|
DRB1*1503- mother (n = 203) |
DRB1*1503+ mother (n = 61) |
| DRB3+ children |
HIV+ (n = 71) |
HIV- (n = 132) |
p value |
odds ratio (95%CI) |
HIV+ (n = 25) |
HIV- (n = 36) |
p value |
odds ratio (95%CI) |
| 66 (93.0%) |
131 (99.2%) |
0.012 |
0.101 (0.012-0.880) |
16 (64.0%) |
29 (80.6%) |
0.148 |
0.429 (0.134-1.370) |
| |
DRB1*1503- children (n = 214) |
DRB1*1503+ children (n = 57) |
| DRB3+ children |
HIV+ (n = 75) |
HIV- (n = 139) |
p value |
odds ratio (95%CI) |
HIV+ (n = 23) |
HIV- (n = 34) |
p value |
odds ratio (95%CI) |
| 69 (92.0%) |
138 (99.3%) |
0.004 |
0.083 (0.010-0.706) |
14 (60.9%) |
26 (76.5%) |
0.207 |
0.479 (0.151-1.516) |
| |
DRB1*1503- mother and children (n = 189) |
DRB1*1503+ mother and children (n = 85) |
| |
HIV+ (n = 65) |
HIV- (n = 124) |
p value |
odds ratio (95%CI) |
HIV+ (n = 33) |
HIV- (n = 49) |
p value |
odds ratio (95%CI) |
| DRB3+ children |
61 (93.8%) |
123 (99.2%) |
0.048 |
0.124 (0.014-1.133) |
22 (66.7%) |
41 (83.7%) |
0.109 |
0.390 (0.137-1.113) |
Inferred neuron-electrophysiology data values
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